4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

Base Information

Chemical Name:4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline
CAS No.:357192-99-5
Molecular Formula:C₁₆H₂₁IN₂O
Molecular Weight:384.26
Hs Code.:

Synonyms:4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

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Chemical Property of 4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

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Technology Process of 4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

There total 3 articles about 4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 357193-08-9
2-(4-amino-phenyl)-1-(7-aza-bicyclo[2.2.1]hept-7-yl)-2-methyl-propan-1-one

: 357192-99-5
4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

Guidance literature:: With Iodine monochloride; calcium carbonate; In methanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)00367-2

Reference yield:

: 83397-45-9
ethyl 2-methyl-2-(4-nitrophenyl)propanoate

: 357192-99-5
4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / NaOH / methanol / 4 h / 60 °C

2.1: (COCl)2; DMF / toluene / 80 °C

2.2: 96 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 2327.17 Torr

4.1: 97 percent / CaCO₃; ICl / methanol; H₂O / 0.5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; Iodine monochloride; N,N-dimethyl-formamide; calcium carbonate; palladium on activated charcoal; In methanol; ethanol; water; toluene;
DOI:10.1016/S0040-4020(01)00367-2

Reference yield:

: 42206-47-3
2-methyl-2-(4-nitro-phenyl)-propionic acid

: 357192-99-5
4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-iodoaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2; DMF / toluene / 80 °C

1.2: 96 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2.1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 2327.17 Torr

3.1: 97 percent / CaCO₃; ICl / methanol; H₂O / 0.5 h / 20 °C

With oxalyl dichloride; hydrogen; Iodine monochloride; N,N-dimethyl-formamide; calcium carbonate; palladium on activated charcoal; In methanol; ethanol; water; toluene;
DOI:10.1016/S0040-4020(01)00367-2