42206-47-3

Basic information

• Product Name: 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID
• Synonyms: 2-Methyl-2-(4-nitrophenyl)propanoic acid;Benzeneacetic acid, .alpha.,.alpha.-dimethyl-4-nitro-
• CAS NO: 42206-47-3
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• Mol File: 42206-47-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 128-129 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)(3:1))
• Boiling Point: 365.9°C at 760 mmHg
• Flash Point: 159.1°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 5.35E-06mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.95±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID(42206-47-3)
• EPA Substance Registry System: 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID(42206-47-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42206-47-3(Hazardous Substances Data)

Usage

General Description

2-Methyl-2-(4-nitrophenyl)-propionic acid is a chemical compound with the molecular formula C11H11NO4. It is a derivative of propionic acid, commonly used as a non-steroidal anti-inflammatory drug (NSAID). 2-METHYL-2-(4-NITROPHENYL)-PROPIONIC ACID is known for its analgesic and antipyretic properties and is often used to relieve pain and reduce inflammation in conditions such as arthritis and other musculoskeletal disorders. It functions by inhibiting the production of pro-inflammatory substances in the body, which helps to alleviate pain and swelling. However, it is important to use this chemical under the guidance of a healthcare professional, as it may cause certain side effects and interactions with other medications.

InChI:InChI=1/C10H11NO4/c1-10(2,9(12)13)7-3-5-8(6-4-7)11(14)15/h3-6H,1-2H3,(H,12,13)

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 74002-19-0 2-methyl-2-(4-nitrophenyl)propanamide 
• 59115-08-1 methyl 2-methyl-2-(4-nitrophenyl)propanoate 
• 770-85-4 2-methyl-2-phenylbutan-3-one 
• 83397-45-9 ethyl 2-methyl-2-(4-nitrophenyl)propanoate 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 
• 826-55-1 2-methyl-2-phenylpropionic acid 

Downstream Products

• 357193-07-8 1-(7-aza-bicyclo[2.2.1]hept-7-yl)-2-methyl-2-(4-nitro-phenyl)-propan-1-one 
• 3276-37-7 1-methyl-1-(4-nitro-phenyl)-ethylamine 
• 1000412-15-6 1-(2-methylpent-4-en-2-yl)-4-nitrobenzene 
• 91133-58-3 3-methyl-3-(4-nitrophenyl)-butan-1-one 
• 18755-53-8 2-methyl-2-(4-nitrophenyl)propan-1-ol 
• 1067193-11-6 {3-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-3-methyl-butyl}-carbamic acid tert-butyl ester 
• 1067191-56-3 N-(4-(4-acetamido-2-methylbutan-2-yl)phenyl)-3,4-dimethoxybenzamide 
• 1067193-12-7 N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide 
• 1067192-96-4 N-(3-(4-aminophenyl)-3-methylbutyl)acetamide 

Relevant articles and documents

Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones

Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.

TYK2 INHIBITORS AND USES THEREOF

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NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 nare defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.