2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

• Chemical Name: 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
• CAS No.: 1393900-47-4
• Molecular Formula: C₂₇H₃₀F₃N₅O
• Molecular Weight: 497.563

Synonyms:2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Chemical Property of 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 13 articles about 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(2-(2-(2-((4-(piperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide (1393900-46-3) → 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide (1393900-47-4)

Guidance literature:

With methanol; sodium tris(acetoxy)borohydride; In water; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

4-nitrophenylboronic acid (24067-17-2) → 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide (1393900-47-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: hydrogenchloride; hydrogen / platinum(IV) oxide / water; methanol / 24 h / 2068.65 Torr / Inert atmosphere

3.1: triethylamine / methanol / 20 h / 20 °C

4.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

4.2: 60 h / 0 - 20 °C

5.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

6.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 22 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride; methanol / water / 2.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; trifluoroacetic acid; zinc(II) chloride; platinum(IV) oxide; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; 10 wt% Pd(OH)2 on carbon; palladium diacetate; triphenylphosphine; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

2-chloropyridine (109-09-1) → 2-(2-(2-(2-((4-(1-methylpiperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide (1393900-47-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 24 h / 80 °C

2.1: hydrogenchloride; hydrogen / platinum(IV) oxide / water; methanol / 24 h / 2068.65 Torr / Inert atmosphere

3.1: triethylamine / methanol / 20 h / 20 °C

4.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

4.2: 60 h / 0 - 20 °C

5.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

6.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 22 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride; methanol / water / 2.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; trifluoroacetic acid; zinc(II) chloride; platinum(IV) oxide; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; 10 wt% Pd(OH)2 on carbon; palladium diacetate; triphenylphosphine; In methanol; diethyl ether; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

4-nitrophenylboronic acid

2-chloropyridine

formaldehyd

2-(2-(2-(2-((4-(piperidin-2-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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