2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

Base Information

Chemical Name:2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester
CAS No.:1026306-11-5
Molecular Formula:C₂₇H₄₀N₂O₁₀
Molecular Weight:552.622
Hs Code.:

Synonyms:2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

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Chemical Property of 2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

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Technology Process of 2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

There total 6 articles about 2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 221077-37-8
(2S)-3-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethoxy]phenyl}2-[(4-methoxy-4-oxobutanoyl)amino]propanoic acid

: 1026306-11-5
2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm010393s

Reference yield:

: 14064-10-9
diethyl 2-chloromalonate

: 1026306-11-5
2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 18 h

2: 87 percent / H₂ / 10percent Pd/C / ethanol / 0.75 h / 1810.07 Torr

3: EDC / CH₂Cl₂ / 18 h / 20 °C

With hydrogen; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm010393s

Reference yield:

: 3878-55-5
methyl hydrogen succinate

: 1026306-11-5
2-{4-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-2-(3-methoxycarbonyl-propionylamino)-ethyl]-phenoxy}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: K₂CO₃ / acetone / 18 h

3: 87 percent / H₂ / 10percent Pd/C / ethanol / 0.75 h / 1810.07 Torr

4: EDC / CH₂Cl₂ / 18 h / 20 °C

With hydrogen; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 10percent Pd/C; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm010393s