{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

Base Information

Chemical Name:{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid
CAS No.:1262132-85-3
Molecular Formula:C₁₆H₁₀F₄N₄O₄
Molecular Weight:398.273
Hs Code.:

Synonyms:{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

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Chemical Property of {[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

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Technology Process of {[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

There total 12 articles about {[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1262133-01-6
C₁₈H₁₄F₄N₄O₄

: 1262132-85-3
{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

Guidance literature:: C₁₈H₁₄F₄N₄O₄; With water; lithium hydroxide; In isopropyl alcohol; at 20 - 70 ℃; for 1h;

With hydrogenchloride; In water; isopropyl alcohol; at 70 ℃; Cooling;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1262132-85-3
{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / Cooling with hexane-dry ice; Inert atmosphere

1.2: 0.5 h / -60 °C / Cooling with hexane-dry ice; Inert atmosphere

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / Inert atmosphere; Cooling with ice

4.1: 1,4-dioxane / 17 h / 94 °C

5.1: toluene-4-sulfonic acid / 1 h / 56 °C

6.1: morpholine / ethyl acetate / 3 h / 74 °C

7.1: lithium hexamethyldisilazane; iodine / tetrahydrofuran / 2 h / -60 °C / Cooling with hexane-dry ice; Inert atmosphere

8.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 80 °C

9.1: sodium hydroxide; water / 1,4-dioxane / 17 h / 20 - 100 °C

9.2: Cooling with ice

10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

11.1: trifluoroacetic acid / 6 h / 80 °C

12.1: water; lithium hydroxide / isopropyl alcohol / 1 h / 20 - 70 °C

12.2: 70 °C / Cooling

With morpholine; potassium phosphate; n-butyllithium; boron trifluoride diethyl etherate; water; iodine; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 262423-77-8
2,4-dichloronicotinic acid

: 1262132-85-3
{[5-(4-fluoro-3-trifluoromethylphenyl)-7-hydroxy[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: boron trifluoride diethyl etherate / tetrahydrofuran / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / Inert atmosphere; Cooling with ice

3.1: 1,4-dioxane / 17 h / 94 °C

4.1: toluene-4-sulfonic acid / 1 h / 56 °C

5.1: morpholine / ethyl acetate / 3 h / 74 °C

6.1: lithium hexamethyldisilazane; iodine / tetrahydrofuran / 2 h / -60 °C / Cooling with hexane-dry ice; Inert atmosphere

7.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 80 °C

8.1: sodium hydroxide; water / 1,4-dioxane / 17 h / 20 - 100 °C

8.2: Cooling with ice

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

10.1: trifluoroacetic acid / 6 h / 80 °C

11.1: water; lithium hydroxide / isopropyl alcohol / 1 h / 20 - 70 °C

11.2: 70 °C / Cooling

With morpholine; potassium phosphate; boron trifluoride diethyl etherate; water; iodine; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;