4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate

Base Information

• Chemical Name: 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate
• CAS No.: 1370262-24-0
• Molecular Formula: C₂₉H₂₁FN₂O₃S
• Molecular Weight: 496.562
• Mol file: 1370262-24-0.mol

Synonyms:4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate

Chemical Property of 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate

There total 2 articles about 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 3,3'-((4-hydroxyphenyl)methylene)bis(1H-indole) (151358-47-3) → 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate (1370262-24-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.2174/157018012799129774

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(di(1H-indol-3-yl)methyl)phenyl 4-fluorobenzenesulfonate (1370262-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium(III) triflate / acetonitrile

2: dmap; triethylamine / dichloromethane / 0 - 20 °C

With dmap; aluminium(III) triflate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.2174/157018012799129774

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

3,3'-((4-hydroxyphenyl)methylene)bis(1H-indole)

4-hydroxy-benzaldehyde