2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

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Chemical Name:2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol
CAS No.:1350351-41-5
Molecular Formula:C₂₃H₂₄N₄O₃S
Molecular Weight:436.535
Hs Code.:

Synonyms:2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

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Chemical Property of 2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

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Technology Process of 2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

There total 6 articles about 2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.5%

: 1350351-58-4
tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

: 1350351-41-5
2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

Guidance literature:: tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

With C₅H₁₁PolS₂; for 0.25h;

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1350351-41-5
2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

2.2: 2.17 h / 20 °C / Cooling with ice

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: sodium carbonate / water; methanol / 1 h / 20 °C

5.1: triethylamine / dichloropalladium triethylphosphane / 1.17 h / 120 °C / Sealed tube

6.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

6.2: 0.25 h

With dmap; N-Bromosuccinimide; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloropalladium triethylphosphane; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1350351-41-5
2-amino-1-(4-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 1 h / 60 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

3.2: 2.17 h / 20 °C / Cooling with ice

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium carbonate / water; methanol / 1 h / 20 °C

6.1: triethylamine / dichloropalladium triethylphosphane / 1.17 h / 120 °C / Sealed tube

7.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

7.2: 0.25 h

With dmap; potassium phosphate; N-Bromosuccinimide; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; dichloropalladium triethylphosphane; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;