tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Chemical Name:tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate
CAS No.:1350351-58-4
Molecular Formula:C₃₈H₄₈N₄O₉S
Molecular Weight:736.887
Hs Code.:

tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Synonyms:tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Chemical Property of tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

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Technology Process of tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

There total 5 articles about tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1350351-58-4
tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

2.2: 2.17 h / 20 °C / Cooling with ice

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: sodium carbonate / water; methanol / 1 h / 20 °C

5.1: triethylamine / dichloropalladium triethylphosphane / 1.17 h / 120 °C / Sealed tube

With dmap; N-Bromosuccinimide; sodium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloropalladium triethylphosphane; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1350351-58-4
tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 1 h / 60 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

3.2: 2.17 h / 20 °C / Cooling with ice

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium carbonate / water; methanol / 1 h / 20 °C

6.1: triethylamine / dichloropalladium triethylphosphane / 1.17 h / 120 °C / Sealed tube

With dmap; potassium phosphate; N-Bromosuccinimide; sodium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; dichloropalladium triethylphosphane; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1349151-83-2
3-bromo-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1350351-58-4
tert-butyl tert-butoxycarbonyl(3-((4-(2-((tert-butoxycarbonyl)amino)-1-hydroxyethyl)phenyl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 0 °C / Cooling with ice

1.2: 2.17 h / 20 °C / Cooling with ice

2.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

3.1: sodium carbonate / water; methanol / 1 h / 20 °C

4.1: triethylamine / dichloropalladium triethylphosphane / 1.17 h / 120 °C / Sealed tube

With dmap; sodium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloropalladium triethylphosphane; In methanol; dichloromethane; water; N,N-dimethyl-formamide;