2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene

Base Information

• Chemical Name: 2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene
• CAS No.: 306739-73-1
• Molecular Formula: C₂₃H₃₄O
• Molecular Weight: 326.522
• Mol file: 306739-73-1.mol

Synonyms:2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene

Chemical Property of 2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene

There total 1 articles about 2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6) → 2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene (306739-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KH / tetrahydrofuran / 3 h

1.2: 81 percent / tetrahydrofuran / 1 h / -50 - 20 °C

2.1: 9.63 g / n-BuLi / tetrahydrofuran; hexane / 20 h / -28 °C

With n-butyllithium; potassium hydride; In tetrahydrofuran; hexane; 1.1: deprotonation / 1.2: Substitution / 2.1: Substitution;

DOI:10.1021/jo0005621

Reference yield:

2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene (306739-73-1) → 2-[(R)-1-((Z)-hexa-1,5-dienyloxy)ethyl]-1,3,5-triisopropylbenzene (306739-87-7)

Guidance literature:

With 1-hexene; hydrogen; Pd-BaSO₄; In pyridine; at 0 ℃; for 4h;

DOI:10.1021/jo0005621

Reference yield:

2-[(R)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene (306739-73-1) → (3R,4S)-4-but-3-enyl-2,2-dichloro-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]cyclobutanone (306739-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.18 g / H₂; 1-hexene / Pd/BaSO₄ / pyridine / 4 h / 0 °C

2: 11.03 g / Zn-Cu / diethyl ether

With 1-hexene; hydrogen; copper; zinc; Pd-BaSO₄; In pyridine; diethyl ether; 1: Catalytic hydrogenation / 2: Cyclization;

DOI:10.1021/jo0005621

upstream raw materials:

(R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol

Downstream raw materials:

2-[(R)-1-((Z)-hexa-1,5-dienyloxy)ethyl]-1,3,5-triisopropylbenzene

(3R,4S)-4-but-3-enyl-2,2-dichloro-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]cyclobutanone