(R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol

Base Information

• Chemical Name: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol
• CAS No.: 181531-14-6
• Molecular Formula: C17H28 O
• Molecular Weight: 248.409
• Mol file: 181531-14-6.mol

Synonyms:Benzenemethanol,a-methyl-2,4,6-tris(1-methylethyl)-,(R)-

Chemical Property of (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol

Chemical Property:

• Melting Point: 86-90 °C
• PSA: 43.60000
• LogP: 2.79310
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol ≥96.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: R(+) & S(-) Stericol Chiral Auxiliaries

Technology Process of (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol

There total 13 articles about (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1'-(2'',4'',6''-triisopropylphenyl)ethyl acetoxyacetate (1400563-23-6) → (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7) + (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6)

Guidance literature:

With methanol; potassium carbonate; Reflux;

DOI:10.1016/j.molcatb.2012.05.006

Reference yield:

(+/-)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7,24226-23-1) → (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7) + (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / 4 h / 20 °C

2: methanol; potassium carbonate / Reflux

With pyridine; methanol; dmap; potassium carbonate;

DOI:10.1016/j.molcatb.2012.05.006

Reference yield:

1,3,5-triisopropyl benzene (717-74-8) → (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 99.6 g / AlCl₃ / CS₂ / 1 h / Heating

2: LiAlH₄ / diethyl ether / 2 h / Heating

3: 165.0 g / N,N-dimethylaminopyridine / pyridine / 2 h / 100 - 110 °C

5: aq. KOH / methanol / 2.5 h / Heating

With dmap; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; In pyridine; methanol; carbon disulfide; diethyl ether;

DOI:10.1016/0957-4166(96)00348-5

upstream raw materials:

Phthalic acid mono-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethyl] ester

1,3,5-triisopropyl benzene

(+/-)-1-(2,4,6-triisopropylphenyl)ethanol

1-(2,4,6-triisopropylphenyl)ethanone

Downstream raw materials:

2-{(1R)-1-[(3-phenyl-1-propynyl)oxy]ethyl}-1,3,5-triisopropylbenzene

(1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate

2-[(R)-1-((E)-1,2-dichlorovinyloxy)ethyl]-1,3,5-triisopropylbenzene

Oxalic acid methyl ester (R)-1-(2,4,6-triisopropyl-phenyl)-ethyl ester