181531-14-6

Basic information

• Product Name: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol
• Synonyms: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol;(R)-Stericol(R);(R)-(+)-STERICOL;(1R)-1-[2,4,6-tri(propan-2-yl)phenyl]ethanol
• CAS NO: 181531-14-6
• Molecular Formula: C₁₇H₂₈O
• Molecular Weight: 248.40362
• Mol File: 181531-14-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 86-90 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol(181531-14-6)
• EPA Substance Registry System: (R)-(+)-1-(2,4,6-Triisopropylphenyl)ethanol(181531-14-6)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 181531-14-6(Hazardous Substances Data)

Usage

Uses

R(+) & S(-) Stericol Chiral Auxiliaries

Upstream product

• 102225-88-7 (+/-)-1-(2,4,6-triisopropylphenyl)ethanol 
• 1400563-22-5 1'-(2'',4'',6''-triisopropylphenyl)ethyl 2,2-dihydroxyacetate 
• 1400563-20-3 1'-(2'',4'',6''-triisopropylphenyl)ethyl hydroxyacetate 
• 1400563-21-4 C₂₀H₂₉NO₃ 
• 1400563-23-6 1'-(2'',4'',6''-triisopropylphenyl)ethyl acetoxyacetate 
• 1400563-30-5 C₂₂H₃₁NO₄ 
• 183201-99-2 Phthalic acid mono-[1-(2,4,6-triisopropyl-phenyl)-ethyl] ester 
• 2234-14-2 1-(2,4,6-triisopropylphenyl)ethanone 
• 717-74-8 1,3,5-triisopropyl benzene 
• 183202-01-9 Phthalic acid mono-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethyl] ester 

Downstream Products

• 1611460-70-8 (R)-O-vinyl-1-(2,4,6-triisopropylphenyl)ethanol 
• 1611460-73-1 methyl (3R,5S)-2-benzyl-3-(2-methoxy-2-oxoethyl)-5-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-83-3 methyl (3R,5S)-3-(2-methoxy-2-oxoethyl)-5-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-80-0 methyl (3R,5S)-2-(4-methoxybenzyl)-3-(2-methoxy-2-oxoethyl)-5-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1166871-11-9 C₁₉H₂₈Cl₂O 
• 1195962-51-6 (R)-(1E)-2-methyl-1-(1-(2,4,6-triisopropylphenyl)ethoxy)-pent-1-en-3-one 
• 181531-18-0 (3R,4S)-2,2-Dichloro-4-isobutyl-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-cyclobutanone 
• 181531-15-7 1,3,5-Triisopropyl-2-[(R)-1-(4-methyl-pent-1-ynyloxy)-ethyl]-benzene 
• 181531-16-8 1,3,5-Triisopropyl-2-[(R)-1-((Z)-4-methyl-pent-1-enyloxy)-ethyl]-benzene 
• 210964-88-8 (+)-(2S,3R)-2-benzyl-4,4-dichloro-3-[(1R)-1-(2,4,6-triisopropylphenyl)ethoxy]cyclobutanone 
• 210964-87-7 (-)-2-{(1R)-1-[((1Z)-3-phenyl-1-propenyl)oxy]ethyl}-1,3,5-triisopropylbenzene 

Relevant articles and documents

Examination of spacer effects on stereochemical recognition of a remote sterically hindered chiral center in lipase-catalyzed acylation

To date, the enzyme-catalyzed kinetic resolution of the secondary alcohol [Ar-C*H(CH3)OH, Ar = 2′,4′,6′- triisopropylphenyl] has not been available, due to high steric hindrance around the hydroxy group. To achieve resolution, the reaction site was extended by the introduction of two kinds of spacers, [-C(=O)CH2] and [-C(=O)C**HCN]. In the first substrate, the recognition of remote chirality [Ar-C*H(CH3)O-C(=O)CH2OH] by acylation with Burkholderia cepacia lipase was examined by changing reaction conditions and acyl donors. An E = 22 in the preference of (1′R)-isomer, was recorded with vinyl acetate as an acyl donor at 25 °C. In the second substrate, there was a matched enantiomeric pair [stereoselective ratio at C-1′ = 15, in the preference of (1′R)-isomer] and a mismatched pair [stereoselective ratio at C-1′ = 2.5, in the preference of (1′S)-isomer] based on the relative stereochemistry between the two chiral centers [Ar- C*H(CH3)O-C(=O)C**HCN-OH].