(1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol

Base Information

• Chemical Name: (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol
• CAS No.: 1092969-78-2
• Molecular Formula: C₅₃H₉₁NO₆
• Molecular Weight: 838.309

Synonyms:(1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol

Chemical Property of (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol

There total 7 articles about (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-1-(benzyloxycarbonylamino)ethyl 3,4,5-tris(dodecanoxy)phenyl ketone (1092969-77-1) → (1S,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol (1092969-80-6) + (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol (1092969-78-2)

Guidance literature:

With sodium tetrahydroborate; ethanol; In water; at 20 ℃; for 6h;

DOI:10.1002/chir.23395

Reference yield: 76.0%

(S)-1-(benzyloxycarbonylamino)ethyl 3,4,5-tris(dodecanoxy)phenyl ketone (1092969-77-1) → (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol (1092969-78-2)

Guidance literature:

With aluminum isopropoxide; In isopropyl alcohol; toluene; at 20 - 50 ℃; diastereoselective reaction;

DOI:10.1002/anie.200803242

Reference yield:

1-bromo-3,4,5-tris-n-dodecyloxybenzene (654065-52-8) → (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol (1092969-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 20 °C

1.2: 3 h / -20 °C

2.1: sodium tetrahydroborate; ethanol / water / 6 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; ethanol; In tetrahydrofuran; water;

DOI:10.1002/chir.23395

upstream raw materials:

(S)-1-(benzyloxycarbonylamino)ethyl 3,4,5-tris(dodecanoxy)phenyl ketone

1-bromo-3,4,5-tris-n-dodecyloxybenzene

(S)-benzyl (1-(N,O-dimethylhydroxylamine)-1-oxopropan-2-yl)carbamate

1-bromo-3,4,5-trimethoxybenzene

Downstream raw materials:

(1S,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propyl benzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1092969-78-2 (1R,2S)-2-(benzyloxycarbonylamino)-1-[3,4,5-tris(dodecanoxy)phenyl]-1-propanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send