3-BROMO-2-METHOXY-6-PICOLINE

Base Information

• Chemical Name: 3-BROMO-2-METHOXY-6-PICOLINE
• CAS No.: 717843-47-5
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• Mol file: 717843-47-5.mol

Synonyms:3-bromo-2-methoxy-6-methylpyridine

Chemical Property of 3-BROMO-2-METHOXY-6-PICOLINE

Chemical Property:

• Vapor Pressure: 0.294mmHg at 25°C
• Refractive Index: 1.538
• Boiling Point: 209.381 °C at 760 mmHg
• PKA: 1.76±0.10(Predicted)
• Flash Point: 80.431 °C
• PSA: 22.12000
• Density: 1.452 g/cm³
• LogP: 2.16110
• Storage Temp.: Room temperature.

Purity/Quality:

98%, ^*data from raw suppliers

3-Bromo-2-methoxy-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-METHOXY-6-PICOLINE

There total 1 articles about 3-BROMO-2-METHOXY-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 3-bromo-6-methoxy-2-methylpyridine (126717-59-7) + 3-bromo-2-methoxy-6-methylpyridine (717843-47-5)

Guidance literature:

With disodium hydrogenphosphate; bromine; In water; at 20 ℃; for 4h;

DOI:10.1039/c3dt52739e

Reference yield: 92.0%

Triisopropyl borate (5419-55-6) + 3-bromo-6-methoxy-2-methylpyridine (126717-59-7) + 3-bromo-2-methoxy-6-methylpyridine (717843-47-5) → 6-methoxy-2-methyl-3-pyridinyl-boronic acid

Guidance literature:

3-bromo-6-methoxy-2-methylpyridine; 3-bromo-2-methoxy-6-methylpyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c3dt52739e

Reference yield: 51.0%

3-bromo-2-methoxy-6-methylpyridine (717843-47-5) → 5-bromo-6-methoxypyridine-2-carboxylic acid (1214334-70-9)

Guidance literature:

With potassium permanganate; tert-butyl alcohol; In water; at 70 ℃; for 20h;

upstream raw materials:

2-methoxy-6-methyl-pyridine

Downstream raw materials:

5-bromo-6-methoxypyridine-2-carboxylic acid