5-Bromo-6-methoxypicolinic acid

Base Information

• Chemical Name: 5-Bromo-6-methoxypicolinic acid
• CAS No.: 1214334-70-9
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00704718
• Wikidata: Q82637225
• Mol file: 1214334-70-9.mol

Synonyms:5-Bromo-6-methoxypicolinic acid;1214334-70-9;5-Bromo-6-methoxypyridine-2-carboxylic acid;5-bromo-6-methoxy-pyridine-2-carboxylic acid;MFCD13185810;5-Bromo-6-methoxypicolinicacid;2-Pyridinecarboxylic acid, 5-bromo-6-methoxy-;SCHEMBL1672188;DTXSID00704718;AMY17230;AKOS016002629;CS-W022332;DS-2238;PB39914;SY103419;3-Bromo-2-methoxy-6-pyridinecarboxylic acid;FT-0746030;A849861

Chemical Property of 5-Bromo-6-methoxypicolinic acid

Chemical Property:

• Boiling Point: 323.8±42.0 °C(Predicted)
• PKA: 3.29±0.10(Predicted)
• PSA: 59.42000
• Density: 1.713±0.06 g/cm3(Predicted)
• LogP: 1.55090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 230.95311
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-6-methoxypicolinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=N1)C(=O)O)Br

Technology Process of 5-Bromo-6-methoxypicolinic acid

There total 3 articles about 5-Bromo-6-methoxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-6-chloropyridine-2-carboxylic acid (959958-25-9) + sodium methylate (124-41-4) → 5-bromo-6-methoxypyridine-2-carboxylic acid (1214334-70-9)

Guidance literature:

In methanol; at 20 - 80 ℃; for 42h;

Reference yield: 51.0%

3-bromo-2-methoxy-6-methylpyridine (717843-47-5) → 5-bromo-6-methoxypyridine-2-carboxylic acid (1214334-70-9)

Guidance literature:

With potassium permanganate; tert-butyl alcohol; In water; at 70 ℃; for 20h;

Reference yield:

3-bromo-2-chloro-6-methyl pyridine (185017-72-5) → 5-bromo-6-methoxypyridine-2-carboxylic acid (1214334-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 168 h / Reflux

2: selenium(IV) oxide / diphenyl ether-biphenyl eutectic / 3 h / 200 °C

With selenium(IV) oxide; In methanol; diphenyl ether-biphenyl eutectic;

upstream raw materials:

3-bromo-2-chloro-6-methyl pyridine

3-bromo-2-methoxy-6-methylpyridine

5-bromo-6-chloropyridine-2-carboxylic acid

sodium methylate

Downstream raw materials:

ethyl 5-bromo-6-methoxypicolinate

Refernces

• 1、 -. "OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF". . . Retrieved 2017/03/14.
• 2、 -. "NOVEL HETEROARYL IMIDAZOLES AND HETEROARYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS". . . Retrieved 2011/05/06.