(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

Base Information

Chemical Name:(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide
CAS No.:1373162-71-0
Molecular Formula:C₃₀H₃₆N₂O₆S
Molecular Weight:552.692
Hs Code.:

Synonyms:(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

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Chemical Property of (R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

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Technology Process of (R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

There total 4 articles about (R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1373162-79-8
(R)-1-(1-benzyl-1H-indol-5-yloxy)-3-(isobutylamino)propan-2-ol

: 23095-31-0
3,4-dimethoxybenzene-1-sulfonyl chloride

: 1373162-71-0
(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2012.02.046

Reference yield:

: 256373-14-5
(-)-5-[((R)-oxiran-2-yl)methoxy]-1H-indole

: 1373162-71-0
(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

2: isopropyl alcohol / 24 h / 20 °C

3: triethylamine / dichloromethane / 24 h / 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.02.046

Reference yield:

: 1373162-75-4
(R)-1-benzyl-5-(oxiran-2-ylmethoxy)-1H-indole

: 1373162-71-0
(R)-N-(3-(1-benzyl-1H-indol-5-yloxy)-2-hydroxypropyl)-N-isobutyl-3,4-dimethoxybenzene sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 24 h / 20 °C

2: triethylamine / dichloromethane / 24 h / 20 °C

With triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2012.02.046