Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Base Information

Chemical Name:Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester
CAS No.:173952-24-4
Molecular Formula:C₂₈H₂₆FN₅O₆
Molecular Weight:547.543
Hs Code.:

Synonyms:Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

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Chemical Property of Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

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Technology Process of Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

There total 10 articles about Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 161417-82-9
2-(acetoxymethyl)-6-(bromomethyl)-3,4-dihydro-4-oxo-7-methylquinazolinone

: 173952-02-8
2-Fluoro-4-methylamino-N-(3-nitro-benzyl)-benzamide

: 173952-24-4
Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: With calcium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm950645n

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 173952-24-4
Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

2: 44 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

With diphenyl phosphoryl azide; triethylamine; calcium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm950645n

Reference yield:

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 173952-24-4
Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-methyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / Na₂CO₃ / CH₂Cl₂ / 2 h

2: Na₂CO₃ / dimethylformamide

3: 7percent aq. K₂CO₃ / methanol / 3 h

4: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h

5: diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

6: 44 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

With diphenyl phosphoryl azide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; calcium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n