(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

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Chemical Name:(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester
CAS No.:196950-06-8
Molecular Formula:C₃₂H₄₇N₅O₁₃
Molecular Weight:709.751
Hs Code.:

Synonyms:(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

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Chemical Property of (3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

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Technology Process of (3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

There total 6 articles about (3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 182748-81-8
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

: 196950-06-8
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 6h;
DOI:10.1039/a702410j

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 196950-06-8
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd/C / ethanol / 4 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

6: 97 percent / H₂ / 10percent Pd/C / ethanol / 6 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/a702410j

Reference yield:

: 67729-36-6,60398-40-5
Boc-Phe-O-COO-isoBu

: 196950-06-8
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / ethanol / 4 h

3: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

5: 97 percent / H₂ / 10percent Pd/C / ethanol / 6 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/a702410j