(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

Base Information

Chemical Name:(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester
CAS No.:182748-81-8
Molecular Formula:C₃₉H₅₃N₅O₁₃
Molecular Weight:799.876
Hs Code.:

(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

Synonyms:(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

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Chemical Property of (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

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Technology Process of (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

There total 14 articles about (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 196950-01-3
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyric acid

: 778557-15-6
(R)-2-{2-[((R)-4-Amino-4-methoxycarbonyl-butyryl)-methyl-amino]-acetylamino}-succinic acid 4-benzyl ester 1-methyl ester

: 182748-81-8
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: DOI:10.1016/0040-4039(96)01515-8

Reference yield:

: 182748-83-0
(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyric acid benzyl ester

: 182748-81-8
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / H₂ / 10percent Pd/C / ethanol / 4 h

2: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

3: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/a702410j

Reference yield:

: 67729-36-6,60398-40-5
Boc-Phe-O-COO-isoBu

: 182748-81-8
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 4-benzyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / ethanol / 4 h

3: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/a702410j