(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

Base Information

Chemical Name:(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester
CAS No.:182748-82-9
Molecular Formula:C₃₈H₄₆F₅N₅O₁₃
Molecular Weight:875.801
Hs Code.:

(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

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Chemical Property of (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

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Technology Process of (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

There total 16 articles about (R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 196950-06-8
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyryl-(α-methyl (2R)-glutamyl)-γ-sarcosyl-(α-methyl (2R)-aspartate) diester

: 182748-82-9
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1039/a702410j

Reference yield:

: 182748-83-0
(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyric acid benzyl ester

: 182748-82-9
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / 10percent Pd/C / ethanol / 4 h

2: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

3: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

4: 97 percent / H₂ / 10percent Pd/C / ethanol / 6 h

5: 61 percent / EDCI / CH₂Cl₂ / 12 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a702410j

Reference yield:

: 196950-01-3
(3R)-3-[(tert-Butoxycarbonyl)-(2S)-phenylalanylamino]-4-hydroxybutyric acid

: 182748-82-9
(R)-2-[2-({(R)-4-[(R)-3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-butyrylamino]-4-methoxycarbonyl-butyryl}-methyl-amino)-acetylamino]-succinic acid 1-methyl ester 4-pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 3 h / Ambient temperature

3: 97 percent / H₂ / 10percent Pd/C / ethanol / 6 h

4: 61 percent / EDCI / CH₂Cl₂ / 12 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a702410j