N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Base Information

Chemical Name:N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine
CAS No.:619334-47-3
Molecular Formula:C₂₁H₁₉N₅O₅
Molecular Weight:421.412
Hs Code.:

Synonyms:N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Suppliers and Price of N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

There total 5 articles about N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108-24-7
acetic anhydride

: 619334-45-1
N-hydroxy-6-{5-[3-(N-hydroxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

: 619334-47-3
N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Guidance literature:: With acetic acid;
DOI:10.1021/jm0302602

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 619334-47-3
N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Guidance literature:: Multi-step reaction with 5 steps

1: 80.6 percent / tetrakis(triphenylphosphine)palladium / dioxane / 24 h / 100 - 110 °C

2: 90.4 percent / N-bromosuccinimide / dimethylformamide / 20 °C

3: 80 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine) palladium / toluene; methanol / 24 h / 80 °C

4: 94 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

5: 100 percent / AcOH

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; acetic acid; In 1,4-dioxane; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: Stille coupling / 3: Suzuki coupling;
DOI:10.1021/jm0302602

Reference yield:

: 619334-28-0
6-(furan-2-yl)nicotinonitrile

: 619334-47-3
N-acetoxy-6-{5-[3-(N-acetoxycarbamimidoyl)-phenyl]-furan-2-yl}-nicotinamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90.4 percent / N-bromosuccinimide / dimethylformamide / 20 °C

2: 80 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine) palladium / toluene; methanol / 24 h / 80 °C

3: 94 percent / hydroxylamine hydrochloride; potassium t-butoxide / dimethylsulfoxide / 20 °C

4: 100 percent / AcOH

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; acetic acid; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1021/jm0302602