(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

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Chemical Name:(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester
CAS No.:464915-34-2
Molecular Formula:C₂₀H₂₇NO₄S
Molecular Weight:377.505
Hs Code.:

Synonyms:(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

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Chemical Property of (1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

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Technology Process of (1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

There total 5 articles about (1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 3696-28-4
2,2'-dipyridyl disulfide bis-N-oxide

: 175415-91-5
(1R,2R)-cyclopropane-1,2-dicarboxylic acid mono-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 464915-34-2
(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

Guidance literature:: With tributylphosphine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja0205232

Reference yield:

: 3811-73-2
2-mercaptopyridine-1-oxide sodium salt

: 178898-59-4
(1R,2R)-2-chlorocarbonyl-cyclopropanecarboxylic acid (1S,2R,5S)-5-isopropyl-2-methyl-cyclohexyl ester

: 464915-34-2
(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

Guidance literature:: With dmap; tetra-(n-butyl)ammonium iodide; In tetrachloromethane; at 20 ℃; for 1h;
DOI:10.1002/1521-3773(20020301)41

Reference yield:

: 96149-01-8
(1R,2R)-cyclopropane-1,2-dicarboxylic acid bis-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 464915-34-2
(1R,2R)-cyclopropane-1,2-dicarboxylic acid 1-(1S,2R,5S)-(5-isopropyl-2-methyl-cyclohexyl) ester 2-(2-thioxo-2H-pyridin-1-yl)ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaOH / propan-2-ol; H₂O / 70 °C

2: 97 percent / SOCl₂ / 20 °C

3: DMAP; Bu₄NI / CCl₄ / 1 h / 20 °C

With dmap; sodium hydroxide; thionyl chloride; tetra-(n-butyl)ammonium iodide; In tetrachloromethane; water; isopropyl alcohol;
DOI:10.1021/ja0205232