Technology Process of 1-[4-methoxy-2-(buta-1,3-diynyl)phenyl]urea
There total 6 articles about 1-[4-methoxy-2-(buta-1,3-diynyl)phenyl]urea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
methanol; water;
at 18 ℃;
for 24h;
DOI:10.1021/ol4007986
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 3 h / -20 °C / Inert atmosphere
1.2: 16 h / -78 - 18 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 18 °C / Inert atmosphere
3.1: methyllithium lithium bromide / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 18 °C / Inert atmosphere
3.2: 24 h / 18 °C / Inert atmosphere
4.1: dichloromethane / 2 h / 0 - 18 °C / Inert atmosphere
5.1: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C
With
methyllithium lithium bromide; tert.-butyl lithium; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; pentane;
3.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol4007986
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 2 h / 18 °C / Inert atmosphere
2.1: methyllithium lithium bromide / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 18 °C / Inert atmosphere
2.2: 24 h / 18 °C / Inert atmosphere
3.1: dichloromethane / 2 h / 0 - 18 °C / Inert atmosphere
4.1: sodium hydrogencarbonate / methanol; water / 24 h / 18 °C
With
methyllithium lithium bromide; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
2.2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol4007986
