KNI-1038

Base Information

• Chemical Name: KNI-1038
• CAS No.: 288399-75-7
• Molecular Formula: C₄₆H₅₉N₉O₁₂S
• Molecular Weight: 962.094
• Mol file: 288399-75-7.mol

Synonyms:KNI-1038

Chemical Property of KNI-1038

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of KNI-1038

There total 5 articles about KNI-1038 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-N-tert-butyl-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (343330-15-4) + Gly-AZT.HCl → KNI-1038 (288399-75-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/S0968-0896(01)00045-1

Reference yield: 70.0%

Amino-acetic acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (182560-18-5) + (R)-N-tert-butyl-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (343330-15-4) → KNI-1038 (288399-75-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00202-X

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → KNI-1038 (288399-75-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide; 4-dimethylaminopyridine / dimethylformamide / 18 h / 20 °C

2: 260 mg / aq. HCl; anisole / dioxane / 1 h / 20 °C

3: 78 percent / Et₃N; 1-hydroxybenzotriazole; [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆ / dimethylformamide / 18 h / 20 °C

With hydrogenchloride; dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00045-1

upstream raw materials:

Amino-acetic acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

(R)-N-tert-butyl-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

3'-azido-2',3'-deoxythymidine

KNI-727

Downstream raw materials:

3'-azido-2',3'-deoxythymidine

KNI-727