8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Base Information

Chemical Name:8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
CAS No.:1207453-27-7
Molecular Formula:C₃₂H₃₃N₅O₄
Molecular Weight:551.645
Hs Code.:

Synonyms:8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Chemical Property of 8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Technology Process of 8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

There total 7 articles about 8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1207453-32-4
4-(9-(4-(4-(isobutyrylpiperazine)-1-carbonyl)phenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde

: 124-40-3
dimethyl amine

: 1207453-27-7
8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

: 1207453-28-8
8-(4-((dimethylamino)methyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: 4-(9-(4-(4-(isobutyrylpiperazine)-1-carbonyl)phenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde; dimethyl amine; In methanol; water; at 20 ℃; for 0.666667h;

With sodium tetrahydroborate; water; In methanol; at 0 ℃; for 2h;

Reference yield:

: 65399-18-0
4-nitrophthalide

: 1207453-27-7
8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

: 1207453-28-8
8-(4-((dimethylamino)methyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: magnesium sulfate / dichloromethane / Reflux

3.1: methanol / 24 h / 0 - 20 °C

4.1: hydrazine hydrate / methanol / 25 °C

5.1: hydrogenchloride / water / 3 h / 20 °C

6.1: water; methanol / 0.67 h / 20 °C

6.2: 2 h / 0 - 20 °C

With hydrogenchloride; hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207453-27-7
8-(4-(hydroxymethyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

: 1207453-28-8
8-(4-((dimethylamino)methyl)phenyl)-9-(4-(4-isobutyrylpiperazine-1-carbonyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: magnesium sulfate / dichloromethane / Reflux

4.1: methanol / 24 h / 0 - 20 °C

5.1: hydrazine hydrate / methanol / 25 °C

6.1: hydrogenchloride / water / 3 h / 20 °C

7.1: water; methanol / 0.67 h / 20 °C

7.2: 2 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;