N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

Base Information

Chemical Name:N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine
CAS No.:119860-22-9
Molecular Formula:C₁₈H₂₇F₂N₃O₄
Molecular Weight:387.427
Hs Code.:

N<sub>1</sub>-Acetyl-N<sub>8</sub>-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

Synonyms:N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

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Technology Process of N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

There total 8 articles about N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7440-44-0
pyrographite

: 119860-21-8
N¹-acetyl-N⁸-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine

: 119860-22-9
N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

Guidance literature:: With stannous chloride; In ethanol; water;

Reference yield:

: 119860-21-8
N¹-acetyl-N⁸-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine

: 119860-22-9
N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

Guidance literature:: With tin(ll) chloride; In ethanol; for 2h; Heating;
DOI:10.1016/0040-4020(95)00896-G

Reference yield:

: 119860-17-2
8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester

: 119860-22-9
N₁-Acetyl-N₈-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-1,4,8-octanetriamine

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / ammonia gas / diethyl ether / -78 °C

2: 1.) BH₃(CH₃)2S; 2.) sat.hydrogen chloride; 3.) NaHCO₃, Na₂CO₃, / 1.) THF, reflux, 4 h; 2.) Et₂O, 0.45 min; 3.) water/THF, rt, 15 h

3: trifluoroacetic acid / 1.5 h / 0 °C

4: N-methylmorpholine, isobutylchloroformate / acetonitrile; dimethylformamide / 15 h / -20 - 20 °C

5: tin(II) chloride / ethanol / 2 h / Heating

With 4-methyl-morpholine; hydrogenchloride; dimethylsulfide borane complex; ammonia; sodium hydrogencarbonate; sodium carbonate; trifluoroacetic acid; tin(ll) chloride; isobutyl chloroformate; In diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4020(95)00896-G