Technology Process of 1-bromo-3,4,5-trifluoro-2,6-diisopropylbenzene
There total 1 articles about 1-bromo-3,4,5-trifluoro-2,6-diisopropylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum (III) chloride;
at 0 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.201705525
- Guidance literature:
-
1-bromo-3,4,5-trifluoro-2,6-diisopropylbenzene;
With
n-butyllithium;
In
tetrahydrofuran; cyclohexane;
at -78 ℃;
carbon dioxide;
In
tetrahydrofuran; cyclohexane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
1.3: 1 h / 0 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.75 h / -78 °C / Schlenk technique; Inert atmosphere
2.2: 3 h / 20 °C / Schlenk technique; Inert atmosphere
3.1: cyclohexane / 20 °C / Glovebox; Inert atmosphere; Sealed tube
With
tert.-butyl lithium;
In
tetrahydrofuran; diethyl ether; cyclohexane; pentane;
DOI:10.1002/anie.201705525
