(3-AMINO-4-PYRIDINYL)PHENYLMETHANONE

Base Information

• Chemical Name: (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE
• CAS No.: 3810-11-5
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Hs Code.: 2933399090
• Mol file: 3810-11-5.mol

Synonyms:Ketone,3-amino-4-pyridyl phenyl (7CI,8CI);3-Amino-4-benzoylpyridine;(3-Aminopyridin-4-yl)(phenyl)methanone;

Chemical Property of (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE

Chemical Property:

• Melting Point: 126-128 °C
• Boiling Point: 423.7 °C at 760 mmHg
• PKA: 4.03±0.18(Predicted)
• Flash Point: 210.1 °C
• PSA: 55.98000
• Density: 1.215 g/cm³
• LogP: 2.47600
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3-Aminopyridin-4-yl)(phenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE

There total 16 articles about (3-AMINO-4-PYRIDINYL)PHENYLMETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-tert-butoxycarbonylamino-4-benzoylpyridine (112175-40-3) → (3-aminopyridin-4-yl)(phenyl)methanone (3810-11-5)

Guidance literature:

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 25 ℃; for 3.5h;

DOI:10.1139/v87-193

Reference yield: 96.0%

2,2-Dimethyl-N-<4-(hydroxyphenylmethyl)-3-pyridinyl>propanamide (82791-70-6) → (3-aminopyridin-4-yl)(phenyl)methanone (3810-11-5)

Guidance literature:

2,2-Dimethyl-N-<4-(hydroxyphenylmethyl)-3-pyridinyl>propanamide; With manganese(IV) oxide; In dichloromethane; for 40h; Reflux;

With hydrogenchloride; In water; for 16h; Reflux;

Reference yield: 94.0%

N-(4-benzoylpyridin-3-yl)-2,2-dimethylpropionamide (112175-38-9) → (3-aminopyridin-4-yl)(phenyl)methanone (3810-11-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Heating;

DOI:10.1139/v87-193

upstream raw materials:

N-(4-benzoylpyridin-3-yl)-2,2-dimethylpropionamide

3-tert-butoxycarbonylamino-4-benzoylpyridine

4-benzoyl-3-nitropyridine

N-(pyridin-3-yl)pivalamide

Downstream raw materials:

3-tert-butoxycarbonylaminomethylcarbonylamino-4-benzoylpyridine

3-benzyloxycarbonylaminomethylcarbonylamino-4-benzoylpyridine

[(4-Benzoyl-pyridin-3-ylcarbamoyl)-tert-butoxycarbonylamino-methyl]-carbamic acid benzyl ester

3-amino-4-benzoyl-2-chloropyridine

Refernces

• 1、 -. "PROTEIN KINASE INHIBITORS". . . Retrieved 2015/01/09.
• 2、 Kobayashi, Kazuhiro,Kozuki, Taketoshi,Suzuki, Teruhiko. "Synthesis of 4-aryl-1,7-naphthyridine-2(1H)-thiones by the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the corresponding Isocyanides". experimental part. p. 556 - 563. Retrieved 2012/05/20.