112175-38-9

Upstream product

• 1696-17-9 N,N-diethylbenzamide 
• 70298-88-3 N-(pyridin-3-yl)pivalamide 
• 82791-70-6 2,2-Dimethyl-N-<4-(hydroxyphenylmethyl)-3-pyridinyl>propanamide 
• 100-52-7 benzaldehyde 
• 3282-30-2 pivaloyl chloride 
• 462-08-8 pyridin-3-ylamine 
• 6919-61-5 N-methoxy-N-methylbenzamide 

Downstream Products

• 125867-45-0 10-phenyl-6,7,8,9-terahydrobenzo<1,7>naphtyridine 
• 112175-39-0 1,3-dihydro-1-methyl-5-phenyl-2H-pyrido<3,4-e>-1,4-diazepin-2-one 
• 112175-42-5 3-tert-butoxycarbonylaminomethylcarbonylamino-4-benzoylpyridine 
• 15505-59-6 3-benzyloxycarbonylaminomethylcarbonylamino-4-benzoylpyridine 
• 3810-18-2 1,3-dihydro-5-phenyl-2H-pyrido<3,4-e>-1,4-diazepin-2-one 
• 125867-42-7 4-phenyl-1,2-dihydropyrido<3,4-d>-2-pyrimidinone 
• 1373774-82-3 4-(1-phenylethenyl)pyridin-3-amine 
• 1373774-90-3 N-[4-(1-phenylethenyl)pyridin-3-yl]formamide 
• 1373774-98-1 3-isocyano-4-(1-phenylethenyl)pyridine 
• 1373775-06-4 4-phenyl-1,7-naphthyridine-2(1H)-thione 
• 3810-11-5 (3-aminopyridin-4-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Quinolinones as Inhibitors of Translation Initiation Complex

Provided herein are compounds and pharmaceutical compositions comprising quinolinones. The quinolinones and compositions thereof are useful as eukaryotic translation initiation factor 4F (eIF4F) complex modulators.

Synthesis of 4-aryl-1,7-naphthyridine-2(1H)-thiones by the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the corresponding Isocyanides

A convenient synthis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones 7 has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines 6, generated in situ by the treatment of the respective isocyanides 5 with S 8 in the presence of a catalytic amount of selenium. The isocyanides 5 can be easily prepared from commercially available pyridin-3-amine by conventional organic reactions.

Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase

A novel series of aminopyridine N-oxides were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFR production in human whole blood. Structure-activit

Synthesis of aza analogues of the anticancer agent batracylin

Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin.

Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives

The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.