N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

Base Information

Chemical Name:N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine
CAS No.:1229017-34-8
Molecular Formula:C₂₃H₃₄BrN₅O₂
Molecular Weight:492.459
Hs Code.:

Synonyms:N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

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Chemical Property of N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

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Technology Process of N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

There total 8 articles about N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1229017-33-7
1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

: 109-89-7
diethylamine

: 1229017-34-8
N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

Guidance literature:: In ethanol; at 70 ℃; for 15h;

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1229017-34-8
N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: pyridine; bromine / dichloromethane / 0.17 h / Cooling with ice

3: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

4: hydrogenchloride; iron / water / 1 h / Reflux

5: triethylamine / ethanol / 3 h / Reflux

6: methanol / 3 h / Reflux

7: ethanol / 15 h / 70 °C

With pyridine; hydrogenchloride; sulfuric acid; bromine; nitric acid; iron; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1229019-44-6
5-bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

: 1229017-34-8
N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

2: hydrogenchloride; iron / water / 1 h / Reflux

3: triethylamine / ethanol / 3 h / Reflux

4: methanol / 3 h / Reflux

5: ethanol / 15 h / 70 °C

With hydrogenchloride; sulfuric acid; nitric acid; iron; triethylamine; In methanol; ethanol; water;