1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

Base Information

Chemical Name:1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea
CAS No.:1229017-33-7
Molecular Formula:C₂₀H₂₇BrN₄O₂S
Molecular Weight:467.43
Hs Code.:

Synonyms:1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

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Chemical Property of 1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

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Technology Process of 1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

There total 7 articles about 1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1229017-32-6
1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea

: 74-88-4
methyl iodide

: 1229017-33-7
1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

Guidance literature:: In methanol; for 3h; Reflux;

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1229017-33-7
1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: pyridine; bromine / dichloromethane / 0.17 h / Cooling with ice

3: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

4: hydrogenchloride; iron / water / 1 h / Reflux

5: triethylamine / ethanol / 3 h / Reflux

6: methanol / 3 h / Reflux

With pyridine; hydrogenchloride; sulfuric acid; bromine; nitric acid; iron; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 63874-26-0
2-n-propoxybenzamidine

: 1229017-33-7
1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: pyridine; bromine / dichloromethane / 0.17 h / Cooling with ice

3: sulfuric acid; nitric acid / 3 h / 20 °C / Cooling with ice

4: hydrogenchloride; iron / water / 1 h / Reflux

5: triethylamine / ethanol / 3 h / Reflux

6: methanol / 3 h / Reflux

With pyridine; hydrogenchloride; sulfuric acid; bromine; nitric acid; iron; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;