tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate
CAS No.:1609654-83-2
Molecular Formula:C₂₅H₃₄F₃N₃O₃
Molecular Weight:481.558
Hs Code.:

Synonyms:tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

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Chemical Property of tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

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Technology Process of tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

There total 5 articles about tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₂F₃N₃O₃

: 1609654-83-2
tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609654-83-2
tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

3.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

4.1: methanol / 4 h / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 2.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; bromine; potassium carbonate; trifluoroacetic acid; In methanol; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; 2.1: |Duff Aldehyde Synthesis / 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;

Reference yield:

: 2198-66-5
2-bromo-4-tert-butylphenol

: 1609654-83-2
tert-butyl (3-((5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzyl)amino)propyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

2.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

3.1: methanol / 4 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 2.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium carbonate; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; water; 1.1: |Duff Aldehyde Synthesis / 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;