5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Base Information

Chemical Name:5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde
CAS No.:1609654-73-0
Molecular Formula:C₁₇H₁₆F₃NO₂
Molecular Weight:323.315
Hs Code.:

Synonyms:5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

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Chemical Property of 5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

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Technology Process of 5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

There total 2 articles about 5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 119646-68-3
3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde

: 1609654-73-0
5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Guidance literature:: 6-(trifluoromethyl)-3-pyridinylboronic acid; 3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.333333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;

Reference yield:

: 2198-66-5
2-bromo-4-tert-butylphenol

: 1609654-73-0
5-(tert-butyl)-2-hydroxy-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere

2.2: 24 h / 80 °C / Inert atmosphere; Sealed tube

With potassium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; water; 1.1: |Duff Aldehyde Synthesis / 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;