2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide

Base Information

• Chemical Name: 2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide
• CAS No.: 137348-64-2
• Molecular Formula: C₁₅H₂₂N₂O
• Molecular Weight: 246.352
• Mol file: 137348-64-2.mol

Synonyms:2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide

Chemical Property of 2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide

There total 6 articles about 2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-N-acetyl-1-phenylethylamine (19144-86-6,6284-14-6) + pivalaldehyde (630-19-3) → 2--N''-<(S)-α-methylbenzyl>acetamide (137348-64-2)

Guidance literature:

DOI:10.1016/0040-4020(95)00091-L

Reference yield: 85.0%

2-amino-N'-(α-phenylethyl)acetamide (137348-67-5,439287-55-5) + pivalaldehyde (630-19-3) → 2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide (137348-64-2)

Guidance literature:

With triethylamine; In dichloromethane; for 5h; Heating;

DOI:10.1016/S0957-4166(00)80465-6

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → 2--N''-<(S)-α-methylbenzyl>acetamide (137348-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / DCC / ethyl acetate / 5 h / 0 °C

2: H₂ / Pd/C / methanol / 35 °C / 7600 Torr

3: Et₃N / CH₂Cl₂ / 5 h / Heating

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jo00125a029

upstream raw materials:

2-amino-N'-(α-phenylethyl)acetamide

pivalaldehyde

2--N''-<(S)-α-methylbenzyl>acetamide

(S)-N-acetyl-1-phenylethylamine

Downstream raw materials:

(2R,1'S)-2-tert-butyl-1-carbobenzyloxy-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

(2S,1'S)-2-tert-butyl-1-carbobenzyloxy-3-(α-methylbenzyl)-1,3-imidazolidin-4-one

(2S)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-imidazolidinone

(2R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-imidazolidinone