{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

Base Information

Chemical Name:{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester
CAS No.:918299-62-4
Molecular Formula:C₃₃H₃₁N₂O₁₁P
Molecular Weight:662.59
Hs Code.:

{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

Synonyms:{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

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Chemical Property of {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

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Technology Process of {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

There total 3 articles about {1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 918299-61-3
C₃₈H₃₉N₂O₁₃P

: 918299-62-4
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 4h; cooling;
DOI:10.1021/jo0617666

Reference yield:

: 1054633-01-0
2',3',5'-tris(O-benzoyl)-4-O-[(2,4,6-triisopropylphenyl)sulfonyl]uridine

: 918299-62-4
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NaH / tetrahydrofuran / 7.5 h / cooling

2: 83 percent / TFA / CH₂Cl₂ / 4 h / cooling

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0617666

Reference yield:

: 1748-04-5
tribenzoyl uridine

: 918299-62-4
{1-[3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)tetrahydrofuran-2-yl]-2-oxo-2,3-dihydro-1H-pyrimidin-4-ylidene}methylphosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / DMAP; triethylamine / CH₂Cl₂ / 10 h / cooling

2: 83 percent / NaH / tetrahydrofuran / 7.5 h / cooling

3: 83 percent / TFA / CH₂Cl₂ / 4 h / cooling

With dmap; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0617666