3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate

Base Information

Chemical Name:3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate
CAS No.:99198-81-9
Molecular Formula:C₂₃H₂₉NO₅S
Molecular Weight:431.553
Hs Code.:
DSSTox Substance ID:DTXSID101133837

Synonyms:SCHEMBL7280409;WHMWRIXHAQNULT-UHFFFAOYSA-N;DTXSID101133837;3-(1-benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate;Phenylmethyl 4-[3-[[(4-methylphenyl)sulfonyl]oxy]propyl]-1-piperidinecarboxylate;99198-81-9

Suppliers and Price of 3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:431.17664420
Heavy Atom Count:30
Complexity:610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCCCC2CCN(CC2)C(=O)OCC3=CC=CC=C3

Technology Process of 3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate

There total 3 articles about 3-(1-Benzyloxycarbonyl-4-piperidyl)propyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 99198-80-8
benzyl 4-(2-hydroxypropyl)-1-piperidinecarboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 99198-81-9
3-(1-benzyloxycarbonyl-4-piperidyl)propyl tosylate

Guidance literature:: In pyridine; for 3h;
DOI:10.1248/cpb.34.3747

Reference yield:

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 99198-81-9
3-(1-benzyloxycarbonyl-4-piperidyl)propyl tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Et₃N / CH₂Cl₂ / 1.75 h / Ambient temperature

2: 58 percent / pyridine / 3 h

With triethylamine; In pyridine; dichloromethane;
DOI:10.1248/cpb.34.3747

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 99198-81-9
3-(1-benzyloxycarbonyl-4-piperidyl)propyl tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Et₃N / CH₂Cl₂ / 1.75 h / Ambient temperature

2: 58 percent / pyridine / 3 h

With triethylamine; In pyridine; dichloromethane;
DOI:10.1248/cpb.34.3747