2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR

Base Information

• Chemical Name: 2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR
• CAS No.: 114414-17-4
• Molecular Formula: BrH*C₅H₅BrN₂O
• Molecular Weight: 269.923
• Hs Code.: 2933399090
• Mol file: 114414-17-4.mol

Synonyms:3-Pyridinol, 2-amino-4-bromo-, monohydrobromide (9CI);

Chemical Property of 2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR

Chemical Property:

• PSA: 59.14000
• LogP: 2.67120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-4-bromopyridin-3-olhydrobromide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR

There total 2 articles about 2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-amino-3-hydroxypyridine (16867-03-1) → 2-amino-4-bromopyridin-3-ol hydrobromide (114414-17-4)

Guidance literature:

With bromine; In ethanol; at 0 - 20 ℃; for 72h;

Reference yield:

2-amino-3-hydroxypyridine (16867-03-1) + hydrogen bromide (10035-10-6,12258-64-9) + copper(ll) bromide (7789-45-9) → 2-amino-4-bromopyridin-3-ol hydrobromide (114414-17-4) + bis(2-amino-4-bromo-3-hydroxypyridinum)hexabromodicuprate(II) dihydrate

Guidance literature:

In water; stoich. amts. of CuBr and the pyridine are reacted in excessive dilute aq. HBr; soln. heated to remove excess of solvent;

Reference yield:

2-amino-4-bromopyridin-3-ol hydrobromide (114414-17-4) → 8-bromo-4-(4-methoxybenzyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / butanone; water / 0.17 h / 0 °C

1.2: 10 h / 0 - 80 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium hydrogencarbonate; caesium carbonate; In water; N,N-dimethyl-formamide; butanone;

upstream raw materials:

2-amino-3-hydroxypyridine

hydrogen bromide

copper(ll) bromide

Refernces

• 1、 -. "MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS". Page/Page column 125. . Retrieved 2018/03/25.