(+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure

Base Information

• Chemical Name: (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure
• CAS No.: 112142-59-3
• Molecular Formula: C₁₆H₂₂N₂O₅
• Molecular Weight: 322.361
• Mol file: 112142-59-3.mol

Synonyms:(+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure

Chemical Property of (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure

There total 4 articles about (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-N,N,2-trimethylpropionamid (87866-93-1) → (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure (112142-59-3)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 60 - 70 ℃;

DOI:10.1002/hlca.19870700209

Reference yield:

(+/-)-2-(2-hydroxy-2-phenylacetamido)-2-methylpropionsaure (111492-26-3) → (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure (112142-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / acetonitrile / 2 h / Ambient temperature

2: 85 percent / HCl / toluene / 0.08 h / 100 °C

3: acetonitrile; H₂O / Ambient temperature

With hydrogenchloride; In water; toluene; acetonitrile;

DOI:10.1002/hlca.19870700209

Reference yield:

(+/-)-2-(2-hydroxy-2-phenylacetamido)-N,N,2-trimethylpropionamid (111492-13-8) → (+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionsaeure (112142-59-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / HCl / acetonitrile; H₂O / 0.17 h / 60 - 70 °C

2: 93 percent / acetonitrile / 2 h / Ambient temperature

3: 85 percent / HCl / toluene / 0.08 h / 100 °C

4: acetonitrile; H₂O / Ambient temperature

With hydrogenchloride; In water; toluene; acetonitrile;

DOI:10.1002/hlca.19870700209

upstream raw materials:

(+/-)-3,3,6,6-tetramethyl-9-phenyl-1-oxa-4,7-diazacyclononan-2,5,8-trion

(+/-)-2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-N,N,2-trimethylpropionamid

(+/-)-2-(2-hydroxy-2-phenylacetamido)-2-methylpropionsaure

(+/-)-2-(2-hydroxy-2-phenylacetamido)-N,N,2-trimethylpropionamid

Downstream raw materials:

(+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

3,3,6,6,9,9,12,12-octamethyl-15-phenyl-1-oxa-4,7,10,13-tetraazacyclopentadecan-2,5,8,11,14-penton

(+/-)-2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

(+/-)-3,3,6,6,9,9-hexamethyl-12-phenyl-1-oxa-4,7,10-triazacyclododecan-2,5,8,11-tetron