N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

Base Information

Chemical Name:N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine
CAS No.:1198109-45-3
Molecular Formula:C₂₂H₂₅F₂N₅O₂
Molecular Weight:429.47
Hs Code.:

Synonyms:N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

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Technology Process of N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

There total 6 articles about N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1198109-92-0
6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

: 51043-72-2
bis(cyclopropyl)methylamine hydrochloride

: 1198109-45-3
N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

Guidance literature:: With triethylamine; In acetonitrile; at 150 ℃; for 1h;

Reference yield:

: 1159694-59-3
4-(difluoromethoxy)-2-methoxyaniline

: 1198109-45-3
N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 24 h / 20 - 80 °C

2: triethylamine / acetonitrile / 21 h / 75 °C

3: acetonitrile / 0.5 h / 160 °C / Microwave irradiation

With hydrogenchloride; triethylamine; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.08.040

Reference yield:

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

: 1198109-45-3
N-(dicyclopropylmethyl)-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 21 h / 75 °C

2: acetonitrile / 0.5 h / 160 °C / Microwave irradiation

With triethylamine; In acetonitrile;
DOI:10.1016/j.bmcl.2011.08.040