6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Base Information

Chemical Name:6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine
CAS No.:1198109-92-0
Molecular Formula:C₁₅H₁₃ClF₂N₄O₂
Molecular Weight:354.744
Hs Code.:

Synonyms:6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Suppliers and Price of 6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Chemical Property:

Purity/Quality:

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Technology Process of 6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

There total 6 articles about 6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445-45-0
Trimethyl orthoacetate

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

: 1198109-92-0
6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Guidance literature:: With acetic acid; In acetonitrile; at 20 ℃; for 89h; Reflux;

Reference yield:

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

: 149-73-5
trimethyl orthoformate

: 1198109-92-0
6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Guidance literature:: With triethylamine; In acetonitrile; at 75 ℃; for 21h;
DOI:10.1016/j.bmcl.2011.08.040

Reference yield:

: 1159694-59-3
4-(difluoromethoxy)-2-methoxyaniline

: 1198109-92-0
6-chloro-9-(4-(difluoromethoxy)-2-methoxyphenyl)-2,8-dimethyl-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 24 h / 20 - 80 °C

2: triethylamine / acetonitrile / 21 h / 75 °C

With hydrogenchloride; triethylamine; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.08.040