6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Base Information

Chemical Name:6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine
CAS No.:1198109-91-9
Molecular Formula:C₁₃H₁₃ClF₂N₄O₂
Molecular Weight:330.722
Hs Code.:

Synonyms:6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

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Chemical Property of 6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

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Technology Process of 6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

There total 3 articles about 6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1159694-59-3
4-(difluoromethoxy)-2-methoxyaniline

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Guidance literature:: With hydrogenchloride; In ethanol; at 20 - 80 ℃; for 24h;
DOI:10.1016/j.bmcl.2011.08.040

Reference yield:

: 1198109-90-8
1-(difluoromethoxy)-3-methoxy-4-nitrobenzene

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dithionite; water / 1,4-dioxane / 2 h / 30 °C

2.1: hydrogenchloride / industrial methylated spirits; water / 16 h / 85 °C

2.2: pH 12

With hydrogenchloride; sodium dithionite; water; In 1,4-dioxane; industrial methylated spirits; water;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1198109-91-9
6-chloro-4-N-(4-difluoromethoxy-2-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium / 24 h / Reflux

1.2: pH 1

2.1: caesium carbonate / water; N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

3.1: sodium dithionite; water / 1,4-dioxane / 2 h / 30 °C

4.1: hydrogenchloride / industrial methylated spirits; water / 16 h / 85 °C

4.2: pH 12

With hydrogenchloride; sodium dithionite; water; sodium; caesium carbonate; In 1,4-dioxane; industrial methylated spirits; water; N,N-dimethyl-formamide;