2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Base Information

Chemical Name:2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole
CAS No.:479541-47-4
Molecular Formula:C₂₀H₁₆N₂O₄
Molecular Weight:348.358
Hs Code.:

Synonyms:2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Suppliers and Price of 2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

There total 8 articles about 2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 479541-49-6
2-O-(3'-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

: 479541-47-4
2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1055/s-2003-41426

Reference yield:

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 479541-47-4
2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 43 percent / imidazole / dimethylformamide; toluene / 2 h / 40 °C

2.1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 40 °C

3.1: 9.88 g / TBAF*H₂O / tetrahydrofuran / 0.25 h / 20 °C

4.1: NaH / dimethylformamide / 1 h / 60 °C

4.2: 93 percent / dimethylformamide / 60 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Mitsunobu reaction;

Reference yield:

: 479541-48-5
(3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-ol

: 479541-47-4
2-O-(3'-cyanophenyl)-5-O-(4''-cyanophenyl)-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 3 steps

1.1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 40 °C

2.1: 9.88 g / TBAF*H₂O / tetrahydrofuran / 0.25 h / 20 °C

3.1: NaH / dimethylformamide / 1 h / 60 °C

3.2: 93 percent / dimethylformamide / 60 °C

With tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;