4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

Base Information

Chemical Name:4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide
CAS No.:934631-73-9
Molecular Formula:C₃₃H₅₁NO₇Si
Molecular Weight:601.856
Hs Code.:

4-[6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-<i>N</i>-methoxy-2,<i>N</i>-dimethyl-butyramide

Synonyms:4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

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Chemical Property of 4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

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Technology Process of 4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

There total 6 articles about 4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 934631-72-8
4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 934631-73-9
4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In tetrahydrofuran; toluene; at 0 - 20 ℃;

4-benzyl-3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-oxazolidin-2-one; In tetrahydrofuran; toluene; at 0 ℃;
DOI:10.1021/ol063143k

Reference yield:

: 934631-68-2
tert-butyl-(4-ethynyl-5,5-dimethyl-3,7-dioxa-bicyclo[4.1.0]hept-2-ylmethoxy)-diphenyl-silane

: 934631-73-9
4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / DIBAL-H / diethyl ether; hexane / 0 °C

2.1: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

3.1: 76 percent / BH₃*SMe₂; 2-methyl-2-butene / tetrahydrofuran / 0 - 20 °C

4.1: Bu₂BOTf; triethylamine / CH₂Cl₂ / -78 - 0 °C

4.2: 93 percent / CH₂Cl₂ / 1.5 h / -78 - 0 °C

5.1: AlMe₃ / tetrahydrofuran; toluene / 0 - 20 °C

5.2: 96 percent / tetrahydrofuran; toluene / 0 °C

With 2-methyl-but-2-ene; dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 4.2: aldol addition;
DOI:10.1021/ol063143k

Reference yield:

: 934631-69-3
6-(tert-butyl-diphenyl-silanyloxymethyl)-2-ethynyl-3,3-dimethyl-tetrahydro-pyran-4-ol

: 934631-73-9
4-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-3-hydroxy-N-methoxy-2,N-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

2.1: 76 percent / BH₃*SMe₂; 2-methyl-2-butene / tetrahydrofuran / 0 - 20 °C

3.1: Bu₂BOTf; triethylamine / CH₂Cl₂ / -78 - 0 °C

3.2: 93 percent / CH₂Cl₂ / 1.5 h / -78 - 0 °C

4.1: AlMe₃ / tetrahydrofuran; toluene / 0 - 20 °C

4.2: 96 percent / tetrahydrofuran; toluene / 0 °C

With 2-methyl-but-2-ene; dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3.2: aldol addition;
DOI:10.1021/ol063143k