toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester
CAS No.:220259-82-5
Molecular Formula:C₁₆H₁₃F₄NO₄S
Molecular Weight:391.343
Hs Code.:

Synonyms:toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

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Chemical Property of toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

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Technology Process of toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

There total 6 articles about toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 98-59-9
p-toluenesulfonyl chloride

: 220259-81-4
2-trifluoromethyl-4-fluoromandelic amide

: 220259-82-5
toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm9810405

Reference yield:

: 90176-80-0
2-(trifluoromethyl)-4-fluorobenzaldehyde

: 220259-82-5
toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) ZnI₂, 2.) 9 N aq. HCl / 1.) overnight, 2.) reflux, overnight

2: 100 percent / HBr

3: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h

4: NH₃ (gas) / toluene; hexane / 1 h

5: 95 percent / diisopropylethylamine / methanol / 3 h / Heating

6: 91 percent / dimethylaminopyridine, DIPEA / CH₂Cl₂

With hydrogenchloride; dmap; oxalyl dichloride; ammonia; hydrogen bromide; N-ethyl-N,N-diisopropylamine; zinc(II) iodide; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9810405

Reference yield:

: 220259-76-7
2-trifluoromethyl-4-fluoromandelic acid

: 220259-82-5
toluene-4-sulfonic acid carbamoyl-(4-fluoro-2-trifluoromethyl-phenyl)-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / HBr

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h

3: NH₃ (gas) / toluene; hexane / 1 h

4: 95 percent / diisopropylethylamine / methanol / 3 h / Heating

5: 91 percent / dimethylaminopyridine, DIPEA / CH₂Cl₂

With dmap; oxalyl dichloride; ammonia; hydrogen bromide; N-ethyl-N,N-diisopropylamine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9810405