Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-

Base Information

Chemical Name:Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-
CAS No.:220259-81-4
Molecular Formula:C9H7 F4 N O2
Molecular Weight:0
Hs Code.:
Mol file:220259-81-4.mol

Synonyms:Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-

Suppliers and Price of Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-

Chemical Property:

PSA：63.32000
LogP:2.06350

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)-

There total 6 articles about Benzeneacetamide, 4-fluoro--alpha--hydroxy-2-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 220259-80-3
O-acetyl-2-trifluoromethyl-4-fluoromandelic amide

: 220259-81-4
2-trifluoromethyl-4-fluoromandelic amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; for 3h; Heating;
DOI:10.1021/jm9810405

Reference yield:

: 90176-80-0
2-(trifluoromethyl)-4-fluorobenzaldehyde

: 220259-81-4
2-trifluoromethyl-4-fluoromandelic amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ZnI₂, 2.) 9 N aq. HCl / 1.) overnight, 2.) reflux, overnight

2: 100 percent / HBr

3: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h

4: NH₃ (gas) / toluene; hexane / 1 h

5: 95 percent / diisopropylethylamine / methanol / 3 h / Heating

With hydrogenchloride; oxalyl dichloride; ammonia; hydrogen bromide; N-ethyl-N,N-diisopropylamine; zinc(II) iodide; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9810405

Reference yield:

: 220259-76-7
2-trifluoromethyl-4-fluoromandelic acid

: 220259-81-4
2-trifluoromethyl-4-fluoromandelic amide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / HBr

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h

3: NH₃ (gas) / toluene; hexane / 1 h

4: 95 percent / diisopropylethylamine / methanol / 3 h / Heating

With oxalyl dichloride; ammonia; hydrogen bromide; N-ethyl-N,N-diisopropylamine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9810405