2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester
• CAS No.: 890409-68-4
• Molecular Formula: C₂₁H₂₁NO₅S
• Molecular Weight: 399.467

Synonyms:2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester

Chemical Property of 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester

There total 2 articles about 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-methoxymethylsalicylate (5446-02-6) + (Z)-3-Bromo-2-ethylsulfanyl-3-(4-methoxy-phenyl)-acrylonitrile (138175-63-0) → 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester (890409-68-4)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃;

DOI:10.1016/j.tetlet.2003.10.072 DOI:10.3987/COM-06-10665

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester (890409-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EtONa / ethanol

1.2: Br₂ / CCl₄

2.1: 81 percent / K₂CO₃ / dimethylsulfoxide / 70 - 80 °C

With sodium ethanolate; potassium carbonate; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2003.10.072

Reference yield: 63.0%

2-[(E)-2-Cyano-2-ethylsulfanyl-1-(4-methoxy-phenyl)-vinyloxy]-4-methoxy-benzoic acid methyl ester (890409-68-4) → 7-methoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromene-3-carbonitrile

Guidance literature:

With aluminium trichloride; In nitrobenzene; at 150 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2003.10.072

upstream raw materials:

4-methoxymethylsalicylate

(Z)-3-Bromo-2-ethylsulfanyl-3-(4-methoxy-phenyl)-acrylonitrile

4-methoxy-benzaldehyde

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