(S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate
• CAS No.: 172945-94-7
• Molecular Formula: C₁₈H₂₈N₂O₆S
• Molecular Weight: 400.496
• Mol file: 172945-94-7.mol

Synonyms:(S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate

Chemical Property of (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate

There total 3 articles about (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

isocyanate de chlorosulfonyle (1189-71-5) + L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) + tert-butyl alcohol (75-65-0) → (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate (172945-94-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.75h;

DOI:10.1016/S0040-4020(00)00114-9

Reference yield:

L-phenylalanine tert-butyl ester (16874-17-2) + N-tert-butyloxycarbonylsulfamoyl chloride (147000-89-3) → (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate (172945-94-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 4h; Yield given;

DOI:10.1080/15257779508009757

Reference yield:

→ (S)-tert-butyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)amino)-3-phenylpropanoate (172945-94-7)

Guidance literature:

In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

upstream raw materials:

L-phenylalanine tert-butyl ester

N-tert-butyloxycarbonylsulfamoyl chloride

isocyanate de chlorosulfonyle

L-phenylalanine tert-butyl ester hydrochloride

Downstream raw materials:

C₂₈H₄₀N₄O₁₀S

C₂₀H₃₁ClN₂O₆S