N-(2-Hydroxyethyl)piperidine-4-carboxamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)piperidine-4-carboxamide
• CAS No.: 30672-46-9
• Molecular Formula: C8H16N2O2
• Molecular Weight: 186.25
• Hs Code.: 2933399090
• European Community (EC) Number: 671-542-9
• DSSTox Substance ID: DTXSID10952920
• Wikidata: Q82931639
• Mol file: 30672-46-9.mol

Synonyms:30672-46-9;N-(2-Hydroxyethyl)piperidine-4-carboxamide;piperidine-4-carboxylic acid (2-hydroxyethyl)amide;Piperidine-4-carboxylic acid (2-hydroxyethyl)-amide;MFCD03425212;piperidine-4-carboxylic acid (2-hydroxy-ethyl)-amide;SCHEMBL670169;DTXSID10952920;SGUNZEMSKPUFDM-UHFFFAOYSA-N;STK066876;AKOS000125845;FS-4861;SB41681;4-[N-(2-hydroxyethyl)carbamoyl]piperidine;FT-0638931;EN300-43018;N-(2-Hydroxyethyl)piperidine-4-carboximidic acid;piperidine-4-carboxylic acid(2-hydroxy-ethyl)-amide;Piperidine-3-carboxylic acid(3-hydroxy-propyl)-amide;Z363998904;piperidine-4-carboxylic acid (2-hydroxyethyl)-amide, AldrichCPR

Chemical Property of N-(2-Hydroxyethyl)piperidine-4-carboxamide

Chemical Property:

• Vapor Pressure: 2.23E-08mmHg at 25°C
• Melting Point: 132-134°C
• Refractive Index: 1.491
• Boiling Point: 408.5 °C at 760 mmHg
• PKA: 14.46±0.10(Predicted)
• Flash Point: 200.9 °C
• PSA: 61.36000
• Density: 1.099 g/cm³
• LogP: -0.18580
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 172.121177757
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

N-(2-hydroxyethyl)piperidine-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C(=O)NCCO

Technology Process of N-(2-Hydroxyethyl)piperidine-4-carboxamide

There total 1 articles about N-(2-Hydroxyethyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-Hydroxy-ethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester (73415-79-9) → N-(2-hydroxyethyl)-4-piperidinecarboxamide (30672-46-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 50 ℃; under 2585.7 Torr;

DOI:10.1021/jm00389a007

Reference yield:

ethanol (64-17-5) + 2,5-dimethoxyquinone (3117-03-1) + N-(2-hydroxyethyl)-4-piperidinecarboxamide (30672-46-9) → C15H20N2O5 (1360078-71-2) + C16H22N2O5 (1360078-68-7)

Guidance literature:

In chloroform; at 150 ℃; for 0.111111h; Microwave irradiation;

Reference yield:

2-(4-(4-cyano-3-methylphenoxy)phenyl)acetic acid + N-(2-hydroxyethyl)-4-piperidinecarboxamide (30672-46-9) → C24H27N3O4

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00111

upstream raw materials:

4-(2-Hydroxy-ethylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

Downstream raw materials:

C₁₅H₂₀N₂O₅

C₁₆H₂₂N₂O₅

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