(1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol

Base Information

• Chemical Name: (1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol
• CAS No.: 1229443-21-3
• Molecular Formula: C₃₄H₄₈NO₃PSi
• Molecular Weight: 577.819

Synonyms:(1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol

Chemical Property of (1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol

Chemical Property:

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Technology Process of (1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol

There total 1 articles about (1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine (1229443-20-2) + diphenylphosphane (829-85-6) → (1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol (1229443-21-3)

Guidance literature:

(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine; diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; hexane; Cooling with ice; Inert atmosphere;

DOI:10.1021/ja103183r

Reference yield: 69.0%

(1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol (1229443-21-3) → 2-(((1S,2R,3R)-3-(diphenylphosphoryl)-2-hydroxycyclohexyl)(methyl)amino)phenol (1229443-10-0)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja103183r

upstream raw materials:

(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

diphenylphosphane

Downstream raw materials:

2-(((1S,2R,3R)-3-(diphenylphosphoryl)-2-hydroxycyclohexyl)(methyl)amino)phenol

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