(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

Base Information

Chemical Name:(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine
CAS No.:1229443-20-2
Molecular Formula:C₂₂H₃₇NO₂Si
Molecular Weight:375.627
Hs Code.:

Synonyms:(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

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Chemical Property of (1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

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Technology Process of (1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

There total 1 articles about (1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1229443-19-9
(1R,2S,6S)-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

: 1229443-20-2
(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

Guidance literature:: With sodium cyanoborohydride; In water; acetic acid; acetonitrile; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ja103183r

Reference yield: 100.0%

: 1229443-20-2
(1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine

: 829-85-6
diphenylphosphane

: 1229443-21-3
(1R,2R,6S)-2-(diphenylphosphoryl)-6-(methyl(2-(triisopropylsilyloxy)phenyl)amino)cyclohexanol

Guidance literature:: (1R,2S,6S)-N-methyl-N-(2-(triisopropylsilyloxy)phenyl)-7-oxabicyclo[4.1.0]heptan-2-amine; diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; hexane; Cooling with ice; Inert atmosphere;
DOI:10.1021/ja103183r