4-Butylpiperidine hydrochloride

Base Information

• Chemical Name: 4-Butylpiperidine hydrochloride
• CAS No.: 372195-85-2
• Molecular Formula: C₉H₁₉N*ClH
• Molecular Weight: 177.717
• Hs Code.: 2933399090
• Mol file: 372195-85-2.mol

Synonyms:Piperidine,4-butyl-, hydrochloride (9CI);

Chemical Property of 4-Butylpiperidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.30700
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DCM, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

4-Butylpiperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Butylpiperidine Hydrochloride is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.

Technology Process of 4-Butylpiperidine hydrochloride

There total 2 articles about 4-Butylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-butylpyridine (5335-75-1) → 4-butylpiperidine hydrochloride (372195-85-2)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

DOI:10.1002/ejoc.201900399

Reference yield:

picoline (108-89-4) → 4-butylpiperidine hydrochloride (372195-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

DOI:10.1002/ejoc.201900399

upstream raw materials:

4-butylpyridine

picoline